姓 名：徐 龙
联系地址：浙江省宁波市镇海区毓秀路505号宁波大学北校区1号实验楼502
电子邮件：xulong@nbu.edu.cn
个人基本信息：男，硕士生导师；2018年6月毕业于四川大学-国家生物材料工程技术研究中心，获生物医学工程专业博士学位，同年7月加入宁波大学材料科学与化学工程学院，从事生物医用材料、纳米药物递送系统及医用小分子凝胶的研发工作。
研究领域：1）功能性纳米载药系统及其在癌症、炎症等领域的研究应用 2）生物医用高分子的设计合成及其应用 3）激响应性小分子凝胶载体的设计合成及应用
研究项目：
1.深层渗透阻断胰腺导管腺癌内神经支配的纳米载药系统，国家自然科学基金-青年基金（2022-2024）；
2.靶向碳酸酐酶XI促进低氧肿瘤转胞吞渗透的新型纳米药物递送系统，浙江省自然科学基金-青年项目（2021-2023）；
3.靶向肿瘤微环境髓源抑制细胞的pH敏感性新型纳米药物传输系统用于癌症免疫治疗的研究，宁波市自然科学基金青年项目（2019-2020）。
发表论文：（2017年至今）
1. Shanming Zhang, Fen Zheng, Kaige Liu, Shengke, Liu, Tonghu Xiao, Yabin Zhu, Long Xu*. Mitochondria-Targeting Polymer Micelles in Stepwise Response Releasing Gemcitabine and Destroying the Mitochondria and Nucleus for Combined Antitumor Chemotherapy. International Journal of Molecular Sciences. 2022. 23. 12624.
2. Caidie Xu,Long Xu*, Renlu Han, Yabin Zhu, Jianfeng Zhang*, Blood circulation stable doxorubicin prodrug nanoparticles containing hydrazone and thioketal moieties for antitumor chemotherapy.Colloids and Surfaces B: Biointerfaces.2021, 201, 11163.
3. Renyuan Chen, Caidie Xu, Yihao Lei, Hongxin Liu*, Yabin Zhu, Jianfeng Zhang and Long Xu*, Facile construction of a family of supramolecular gels with good levofloxacin hydrochloride loading capacity.RSC Advances.2021, 11, 12641–12648.
4. Caidie Xu, Renlu Han, Hongxin Liu,* Yabin Zhu, Jianfeng Zhang, andLong Xu*, Construction of polymeric micelles for improving cancer chemotherapy by promoting the production of intracellular reactive oxygen species and self-accelerating drug release.ChemistrySelect.2021, 6, 3277–3285.
5. Long Xu, Mingying Zhao, Wenxia Gao⁎, Yidi Yang, Jianfeng Zhang, Yuji Pu，Bin He*. Polymeric nanoparticles responsive to intracellular ROS for anticancer drug delivery.Colloids and Surfaces B: Biointerfaces.2019, 181, 252–260.
6. Long Xu, Mingying Zhao, Hai Zhang, Wenxia Gao*, Zhaoyuan Guo, Xuequan Zhang, Jianfeng Zhang, Jun Cao, Yuji Pu, and Bin He*. Cinnamaldehyde-Based Poly(ester-thioacetal) To Generate Reactive Oxygen Species for Fabricating Reactive Oxygen Species Responsive Nanoparticles.Biomacromolecules.2018, 19, 4658-4667.
7. Long Xu, Yidi Yang, Mingying Zhao, Wenxia Gao*, Hai Zhang, Sai Li, Bin He and Yuji Pu*. A reactive oxygen species–responsive prodrug micelle with efficient cellular uptake and excellent bioavailability.Journal of Materials Chemistry B.2018, 6, 1076-1084.
8. Long Xu, Mingying Zhao, Yidi Yang, Yan Liang, Changzhen Sun, Wenxia Gao,* Sai Li, Bin He and Yuji Pu*. A reactive oxygen species (ROS)-responsive low molecular weight gel co-loaded with doxorubicin and Zn(II) phthalocyanine tetrasulfonic acid for combined chemo-photodynamic therapy.Journal of Materials Chemistry B.2017, 5, 9157-9164.
9. Long Xu#, Yan Liang#, Changzheng Sun, Na Hao, Jianqin Yan, Wenxia Gao*, Bin He*. Substitution of Percutaneous Ethanol Injection with a Low Molecular Weight Peptide Gel Mimicking Chemoembolization for Cancer Therapy.Nanotheranostics.2017, 1, 313-325.
授权专利：
1. 徐龙，李民媛，丁钱晶，徐彩蝶。免疫治疗纳米药物载体及其制备方法和具有该载体的药物和该药物的制备方法，中国发明专利，专利号：ZL202011259453.8，授权公告日：2022.06.14。
2. 徐龙，张善铭，刘圣珂。 一种深层渗透阻断肿瘤神经支配的乏氧/ROS响应型聚合物前药，中国发明张利，专利号ZL20211147208.0。
诚挚欢迎有志之士加入我们！
