报告人：Prof. Timothy J. Deming
Timothy Deming received his B.S. in Chemistry from the University of California, Irvine in 1989, and his Ph.D. in Chemistry from the University of California, Berkeley, in 1993. After a NIH postdoctoral fellowship at the University of Massachusetts, Amherst, he joined the faculty in the Materials Department at the University of California, Santa Barbara in 1995. Here he held a joint appointment in the Materials and Chemistry Departments where he was promoted to Associate Professor in 1999 and Full Professor in 2003. In 2004 he moved to UCLA where he is now as Professor in the Bioengineering Department and Professor of Chemistry and Biochemistry.
Although natural amino acids provide polypeptides with abundant functionality, there is increasing interest in the addition of functional groups not found in natural amino acids. There may include functionalities that are incorporated into peptides and proteins by post-translational modifications may be desired to improve or add properties that may be useful for applications in biotechnology. Using transition metal catalysis chemistry for the polymerization of alpha-amino acid-N-carboxyanhydrides (NCAs), we have prepared synthetic polypeptides based on natural amino acids that are readily and chemoselectively functionalized using simple reagents under mild conditions. These reactions allow the post polymerization modification of peptide polymers to give bioconjugates containing a broad range of functional groups not present in natural protein. The use of these functional residues in controlling assembly of block copolypeptides and their application in therapeutic delivery applications will be presented.